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 Women randomized to estrogen and progestin had significantly elevated risks for coronary heart disease, breast cancer, stroke, pulmonary embolism, dementia (in women 65 years of age and older), gallbladder disease, and urinary incontinence. On the other hand, they were at reduced risk for hip fractures, diabetes, and vasomotor symptoms. After discontinuation of therapy most of the effects, both positive and negative, were no longer apparent, though a small increase in breast cancer risk remained.
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